Comparison of two doses of intranasal dexmedetomidine as premedication in children

Introduction In this study we are comparing two different doses 1μg/kg and 2 μg/kg of intranasal dexmedetomidine for sedative efficacy and analgesia as a premedication in children (6-12 years of age). This prospective, randomized study is designed to evaluate efficacy of 2 different doses of intranasal dexmedetomidine as a premedication in children. To assess the patient preoperatively and its importance in anesthetic management. To evaluate the sedative, anxiolytic, and analgesic effects of dexmedetomidine at dose of 1 μg/kg and 2 μg/kg when administered through intranasal route in paediatric patient. To compare efficacy of these two different doses as a premedication. To study hemodynamic variations that occurs after administration of intranasal dexmedetomidine. Materials and Methods Patients were categorized in 2 groups: Group A: Intranasal Dexmedetomidine 1 μg/kg (n = 25) Group B: Intranasal Dexmedetomidine 2 μg/kg (n = 25) Group A and B received the drug at 45 minutes before induction of anesthesia. Various parameters were recorded. A value of p < 0.05 was considered as a statically significant difference with ANOVA being done along with krushual-wall’s test. Sedation and hemodynamic data were analysed by mixed model analysis of crossover. Bonferroni-T-test was used for pair wise comparison. Results and conclusions The group which was administered 2 mcg/kg of intranasal dexmedetomidine showed better results in terms of sedation and behavioural scores , intraoperative hemodynamics , post-operative recovery as compared to the group given 1 mcg/kg of the drug.